Xiaoran Zhang

Toxicokinetics, Biotransformation, and Tissue Distribution of Imidaclothiz in Rats

Abstract Imidaclothiz (IMZ), a next-generation neonicotinoid pesticide, has garnered significant attention due to its detection in human samples. In this study, we investigated its toxicokinetics and biotransformation in rats following oral administration. IMZ was rapidly absorbe...

Functionally active lymphoid aggregates correlate with improved prognosis in brain metastases

Abstract B cells and their cellular neighborhoods, i.e., lymphoid aggregates (LAs) and tertiary lymphoid structures (TLS), have not been extensively studied in melanoma brain metastases (BM) or lung adenocarcinoma (LUAD) BM, despite their prognostic value and role in immunotherap...

Unmasking aminated graphene quantum dots neurotoxicity in freshwater planarian: Dopaminergic disruption and reversible motor dysfunction at sublethal doses

Despite their favorable biocompatibility profile, the neurotoxic potential of aminated graphene quantum dots (A-GQDs) remains poorly characterized, especially concerning their environmental impact. Utilizing the planarian Dugesia japonica , a freshwater invertebrate model with a...