Xiaoping Liu

Charting critical transient gene interactions in disease progression across bulk, single-cell, and spatial transcriptomics

Critical transitions in gene regulatory networks presage abrupt disease shifts, yet existing tools rank signals unsupervised at gene/module level, use unweighted enrichments, and underuse multimodal data. We present CRISGI, which models interaction-level critical transition dynam...

Emerging compound air-soil heatwaves amplify global vegetation losses

Abstract Compound air-soil heatwaves—periods in which extreme air and soil temperatures co-occur—pose a growing threat to terrestrial ecosystems, yet their occurrence and impacts remain poorly understood. Here, we show that compound air-soil heatwaves have become more frequent (0...

HyperLayout: A decoupled and planning-oriented framework for parcel-level building layout generation

Urban development is increasingly shifting from outward expansion toward the renewal and optimization of existing urban areas. This transition has created a growing demand for building layout generation methods that can satisfy complex planning requirements while maintaining soun...