Xiaoning Qian

Integrating Data Cleaning and Robustification: A Study on Linear Regression

In this study, we propose a general framework that integrates both optimistic and pessimistic optimization approaches in solving the regression problem to address outlier cleaning and robustification in a unified fashion. Although data cleaning aims to down-weight the outliers, r...

Structure-based TCR-pMHC binding prediction and generalization to unseen peptides

Abstract The interaction between T-cell receptors (TCRs) with the peptide-bound major histocompatibility complex (MHC) intricately impacts the functional specificity of T-cell-mediated adaptive immune response. Consequently, implication in immunotherapy has contributed to the eve...