Xiaoling He

Dynamics of human cardiogenesis and its disruption in trisomy 21

Abstract Developmental dynamics involve the specification of diverse cell types and their spatial organization into multicellular niches 1 . Here we combine single-cell and spatial multiomics to define 21 distinct tissue niches in the developing heart, which we use to develop a c...

Spatially resolved multiomics of human meningeal development reveal lineage and disease dynamics

Abstract The meninges are increasingly recognized as key stromal and immune niches supporting cranial development. Here we constructed a paired single-nuclei RNA and Assay for Transposase-Accessible Chromatin atlas of human meningeal development from 6 to 21 postconception weeks...

Effects of dapagliflozin on inflammatory biomarkers and cardiac function in patients with acute myocardial infarction after percutaneous coronary intervention and type 2 diabetes: an exploratory observational study with propensity score matching

Abstract Background Acute myocardial infarction (AMI) triggers a robust inflammatory response that contributes to adverse ventricular remodeling. Sodium-glucose cotransporter-2 (SGLT2) inhibitors have demonstrated anti-inflammatory properties beyond glycemic control, but their ef...