Xiaolan Zhao

Loss of human SMC5/6 induces spindle multipolarity and genome stress exacerbated by BLM helicase deficiency

Abstract Mutations of the human SMC5/6 genome maintenance complex can lead to several genome instability syndromes and are associated with tumorigenesis. However, the molecular consequences of SMC5/6 deficiencies in human cells are only partly known, preventing a better understan...