Xiaojin Zhang

Insights into HIF Prolyl Hydroxylase Inhibitors: Recent Advances and Expanding Therapeutic Applications beyond Anemia

Abstract Oxygen homeostasis is fundamental to cellular and organismal physiology and is primarily governed by the hypoxia-inducible factor (HIF) signaling pathway. Within this pathway, prolyl hydroxylase domain enzymes (PHDs) serve as a key oxygen sensor that regulates HIF-α stab...