Xiaoguang Lei

Nigral DJ-1 gene knockout in tree shrews can induce phosphorylated α-synuclein aggregation and all key phenotypes of Parkinson’s disease

Abstract DJ-1 is a genetic factor associated with Parkinson’s disease (PD), and altered DJ-1 function has been implicated in PD pathogenesis. However, DJ-1 knockout mice fail to reproduce robust PD-like phenotypes or neuropathology, leaving the contribution of DJ-1 deficiency to...