Xiaochen Liang

HMGB1 andHMGB2 Are O 4-Alkylthymidine-BindingProteins

Abstract Exposure to endogenous and exogenous sources of alkylating agents leads to DNA lesions that can impair cell survival and confer genome instability by eliciting mutations during DNA replication and transcription. Among the DNA alkylation adducts, O4-alkylthymidine (O4-alk...