Xiaoao Pang

Integrated multi-omics, spatial transcriptomics, and functional studies implicate MDK as a mediator of cisplatin-response phenotypes in ovarian cancer

Abstract Platinum resistance remains a central barrier to durable disease control in ovarian cancer. In this study, we integrated an ovarian cancer susceptibility GWAS, multi-omics profiling (CPTAC/TCGA), and spatial-single-cell transcriptomics to identify novel therapeutic targe...