Xiao-Yong Zhan

mRNA-LNP vaccines targeting conserved virulence factors elicit protective immunity against lethal Legionella pneumophila infection

Legionnaires’ disease (LD), caused by the intracellular pathogen Legionella pneumophila , imposes a substantial global health burden, yet no vaccine has been clinically approved. Here, we develop mRNA-LNP vaccines encoding conserved virulence factors Pal, PilE, and FlaA. In BALB/...

Genomic divergence and phenotypic heterogeneity of Legionella longbeachae reveal a putative novel proinflammatory serogroup with genome reduction and mobilome expansion

ABSTRACT Legionella longbeachae is an emerging respiratory pathogen primarily found in soil environments, yet its genomic architecture and evolutionary strategies remain poorly characterized. Here, through pan-genomic and functional analysis of 242 L. longbeachae isolates, we rev...