Xiao Chen

Integrated multi-omic analysis characterizes an IFNγ-responsive-to-myeloid-suppressive immune continuum in immune-active hepatocellular carcinoma

Immune-active hepatocellular carcinoma (HCC) is commonly treated as a single inflamed phenotype, although its internal immune heterogeneity remains incompletely defined. We integrated public bulk transcriptomic, single-cell, spatial transcriptomic, proteomic, phosphoproteomic, an...

Stress-resolved longitudinal single-cell and spatial transcriptomic analysis supports a tumor–immune remodeling framework during chemoradiotherapy in cervical cancer

Concurrent chemoradiotherapy (CRT) is standard for locally advanced cervical cancer, but early links between tumor adaptation and immune dysfunction remain incompletely resolved. We conducted an exploratory secondary analysis of public longitudinal single-cell RNA-sequencing data...