Xian‐Zheng Zhang

Self‐Assembled Dual‐Drug Nanoparticles for Tumor‐Targeted Delivery and Enhanced Antitumor Chemo‐Immunotherapy

ABSTRACT Insufficient tumor‐targeting accumulation and the immunosuppressive tumor microenvironment (TME) greatly restrict the efficacy of chemo‐immunotherapy. Herein, AWS@PTNC nanoparticles (NPs) are elaborately fabricated via self‐assembly of paclitaxel dimer and serine synthes...

Biotactic Nanodrugs Induce Tumor‐Localized and Durable Embolization via Programmatic Participation in Physiological Biochemical Reactions

The clinical application of tumor vascular obstruction therapy (TVOT) is mainly hindered by imprecise obstruction localization and transient embolic effects. We developed a biotactic nanodrug termed PDA-A@Fib to achieve precise and sustained TVOT by programmatically participating...