Xianling Cong

Snail2: roles and regulatory mechanisms in development and disease

Abstract Snail2 (SNAI2/Slug), a core C2H2 zinc-finger transcription factor of the Snail superfamily, functions as a master regulator of epithelial-mesenchymal transition (EMT) and cellular plasticity in development and disease. Unlike other EMT transcription factors that drive co...

Glycolytic reprogramming and the EMT drive cervical cancer progression via the NQO1/HIF1α-SIX1 axis

Cervical cancer aggressiveness and therapeutic resistance are driven by metabolic reprogramming and redox imbalance. Within this context, NAD(P)H: quinone oxidoreductase 1 (NQO1), a critical regulator of cellular redox homeostasis and energy metabolism, is highly expressed in sev...