Xiangwei Gao

Translational control by RPL22L1-specific ribosomes enhances DNA repair and chemoresistance

Ribosome heterogeneity has emerged as a regulatory layer in gene expression, yet its biological roles in cancers remain poorly characterized. Here, we identify RPL22L1, a paralog of the ribosomal protein RPL22, as a key modulator of DNA damage response (DDR) in colorectal cancer...