Xiancang Ma

IL-6 signaling drives treg dysfunction and pathogenic Th1-like polarization in major depressive disorder

Major depressive disorder (MDD) is pathologically associated with inflammatory-immune dysregulation. While regulatory T cells (Tregs) are essential for immune homeostasis, clinical evidence have reported paradoxical dynamics (deficiency vs. expansion) of peripheral Tregs in MDD p...

Dysbiosis of the oral-gut microbiome axis in a mouse model of depression

This study aimed to characterize the alterations in both oral and gut microbiota in a mouse model of depression and to explore their potential role in the pathogenesis of major depressive disorder (MDD) through the oral-gut-brain axis. A depression model was established in male C...