Xiahe Han

A tumor-on-a-chip model reveals and targets reciprocal macrophage–NK cell crosstalk to advance immunotherapy screening

Effective cancer immunotherapy is hindered by immunosuppressive crosstalk within the tumor microenvironment. We engineered a tumor immune microenvironment-on-a-chip (TIMoC) that recapitulates the vascularized, hypoxic, and spatially organized niche of human solid liver tumors. We...