Xi Chen

Development of pathology-responsive Cu-based metal–phenolic nanonetworks for disease-modifying treatment of knee osteoarthritis

Objectives Knee osteoarthritis (KOA) is characterized by chronic inflammation, oxidative stress, and extracellular matrix (ECM) degradation, while current therapies mainly provide symptomatic relief. We developed a pathology-responsive copper-based metal-phenolic nanonetwork (Cu-...

MicroRNA expression profiling in fowl adenovirus serotype 4-infected Leghorn male hepatoma cells using small RNA deep sequencing

Fowl adenovirus serotype 4 ( FAdV-4 ) is the causative agent of hydropericardium-hepatitis syndrome ( HHS ), a disease that causes severe economic losses to the global poultry industry. MicroRNAs ( miRNAs ) are key regulators of host–pathogen interactions; yet, their temporal exp...