Xavier Hanoulle

Glycans located upstream of the furin cleavage site in SARS-CoV-2 Spike protein influence its processing and functions

The SARS-CoV-2 Spike (S) glycoprotein, which plays a central role in viral entry, consists of two subunits: S1, which mediates binding to the ACE2 receptor; and S2, which induces fusion of the viral envelope with the cell membrane. The S glycoprotein also contains a polybasic mot...