Author
X Zhang
Recent research
- Biology
A patenting perspective of IKZF2 molecular glue degraders (2020-present)
INTRODUCTION: IKZF2 (Helios) maintains the suppressive function of regulatory T cells (Tregs) and is an emerging immuno-oncology target. Its degradation destabilizes Tregs, strengthens antitumor immunity, and may remodel the tumor microenvironment (TME) with reduced off-target to...