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C5aR1-positive PMN-MDSC-induced angiogenesis limits the efficacy of radiotherapy combined with Anti-PD-1 immunotherapy

Radiotherapy (RT) combined with Anti–PD-1 immunotherapy (RT + Anti-PD-1) offers synergistic potential in the treatment of colorectal cancer (CRC). However, RT + Anti-PD-1 often fails to be effective in some patients with CRC, because a subset of tumors exhibits limited responsive...