X Chen

Viral Nuclease Inhibitors: Small molecule disruptors of the UL12 alkaline nuclease display broad anti-herpes virus activity

Abstract Herpes simplex virus-1 (HSV-1) UL12 gene encodes a well-conserved 5’ → 3’ alkaline exonuclease. UL12 collaborates with the HSV single-strand DNA binding protein ICP8 to mediate recombination-dependent replication of viral DNA and is essential for the production of DNA th...