Woosuk Choi

Pseudomonas aeruginosa Pyocyanin Increases Airway Mucin Biosynthesis by SIRT1-Mediated FOXA2 Inactivation

The potent redox-cycling Pseudomonas aeruginosa secondary metabolite pyocyanin induces acute and persistent oxidative stress in diseased airways. Pyocyanin promotes goblet cell hyperplasia and metaplasia and exacerbates the mucus burden. Forkhead Box A2 (FOXA2) is a key pioneer f...