William R. Davis

MDL‐800‐induced SIRT6 activation decreases age‐associated osteoarthritis in mice

OBJECTIVE: SIRT6 is a nuclear-localized histone deacetylase that regulates multiple pathways associated with aging. This study aimed to determine whether systemic administration of a small molecule activator of SIRT6, MDL-800, decreases the severity of age-associated osteoarthrit...