William M. Southerland

Equation Disagreement as a Zero-Cost Uncertainty Signal for LDL-C Classification: An Interpretable Regime-Aware Calibration Model Rescues Misclassification at Treatment Thresholds.

BACKGROUND: Three LDL cholesterol (LDL-C) estimation equations (Friedewald, Sampson/NIH, and Martin-Hopkins) can be calculated from every standard lipid panel, yet laboratories typically report only one. We tested whether disagreement identifies misclassification risk at clinical...