William H. Catherino

Novel orthotopic uterine leiomyosarcoma model demonstrated enhanced tumor growth, metastasis, and chemosensitivity compared to subcutaneous counterparts

Objective: Uterine leiomyosarcoma (uLMS) maintains a poor prognosis due to its aggressive behavior and limited therapeutic response. Preclinical progress is severely hindered by traditional subcutaneous models that often fail to metastasize, despite one-third of uLMS patients dis...