Wenqian Xu

An ENE-related transcriptomic signature predicts distant metastasis risk and immune microenvironment features in nasopharyngeal carcinoma

Extracapsular nodal extension (ENE) is an adverse prognostic factor in nasopharyngeal carcinoma (NPC). In this study, we analyzed RNA-seq data from 159 NPC patients stratified by ENE status, identified differentially expressed genes, and developed an eight-gene machine-learning s...

Design, Synthesis, and Fungicidal Activity Evaluation of 1,2,4-Triazole Fungicides Featuring gem -Difluoromethylthio Moiety

Abstract The gem-difluoroalkylthio (−SCF2−) moiety has achieved great success in medicinal chemistry, but its application in agrochemicals remains underexplored because of synthetic challenges. Herein, we report a series of 1,2,4-triazole derivatives bearing the gem-difluoromethy...