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TREM2 regulates continual efferocytosis of apoptotic neurons by monocyte-derived macrophages via AKT-PFKFB2-mediated glycolytic reprogramming after acute ischemic stroke

Efficient clearance of apoptotic neurons is crucial for mitigating secondary injury after acute ischemic stroke (AIS). Although monocyte-derived macrophages (MDMs) rapidly infiltrate the ischemic brain and upregulate triggering receptor expressed on myeloid cells 2 (TREM2) expres...