Wenjie Zhang

Collagen‐Binding IL‐15 Immunocytokine Armed Oncolytic Adenovirus Establishes a Self‐Reinforcing Immunostimulatory Milieu to Potentiate Antitumor Immunity

ABSTRACT The immunosuppressive microenvironment limits immunotherapy in triple‐negative breast cancer (TNBC). Interleukin‐15 (IL‐15) activates cytotoxic lymphocytes but is limited by rapid clearance and poor tumor retention. Here, we developed an oncolytic adenovirus encoding IL1...

Enhancing the Skatole Degradation Capacity of Lactococcus lactis NZ9000 Through the Heterologous Expression of the Ska Enzyme from Acinetobacter piscicola p38

Skatole is a harmful, odorous pollutant in livestock manure. Skatole-degrading strains are mostly harmful Gram-negative bacteria, whereas safe Gram-positive strains demonstrate poor degradation performance, limiting bioremediation applications. To solve this problem, this study w...

Drilling Performance Evaluation and Mechanism Analysis of Diamond-Coated Drills in Ice-Supported CFRP Machining

Diamond-coated tools are suitable for CFRP machining because of their high hardness, sharp cutting edge, and good wear resistance. However, the anisotropic and heterogeneous nature of CFRP makes drilling-induced defects, such as burrs, tearing, fiber pull-out, and delamination, d...