Wendy P. J. den Elzen

Towards a suitable biomarker for childhood screening for familial hypercholesterolemia: a systematic literature review

Familial hypercholesterolemia (FH) is a common genetic disorder causing elevated low-density lipoprotein cholesterol (LDL-c) concentrations from birth, resulting in a high risk of premature cardiovascular disease. Despite effective early treatment, FH remains underdiagnosed in ch...

How to Establish a Reference Interval: A Practical Approach.

BACKGROUND: Establishing accurate reference intervals (RIs) is essential for interpreting clinical chemistry laboratory test results and ensuring clinical relevance. The aim of this review is to provide a practical guide to determine RIs using direct and indirect methods. CONTENT...