Wencai Chen

Decoding the clinical masking effect in SAA-positive Parkinson’s disease: from central mechanistic dichotomy to a peripheral diagnostic panel

Despite global efforts to develop disease-modifying therapies for Parkinson’s disease (PD), recurrent trial failures persist, likely driven by profound and unstratified molecular heterogeneity. The advent of α-syn seed amplification assays (SAA) has enabled biologically pure coho...