Wen Li Xie

In memory of David J Mangelsdorf: my scientific interactions with Davo

Abstract David J Mangelsdorf was a senior colleague in the field of nuclear receptors who passed away unexpectedly in 2025. Dr Mangelsdorf and I share the same postdoctoral mentor at the Salk Institute. This article reflects on my scientific interaction with Dr Mangelsdorf, inclu...

Desulfinylation of the deubiquitinase USP7 by SRXN1 attenuates oxidative acute liver injury

Protein S -sulfinylation is a reversible oxidative cysteine modification, but its contribution to acute liver injury such as those induced by acetaminophen (APAP) overdose has not been reported. Sulfiredoxin-1 (SRXN1) is the only oxidoreductase known to reduce the sulfinylated pr...