Wen Che

Synthesis of the A/B ring system of withaferin A-type withanolides

Withanolides are C28 steroidal lactone plant-based natural products with diverse pharmacological activities, yet their synthesis remains challenging owing to the highly oxidized A/B ring system. Herein, we report a concise, protecting group-free route to the 1‑oxo‑2‑ene‑4β‑hydrox...