Weiliang Deng

Renal-Clearable Fluorogenic Nanoprobes for Molecular Imaging of Hepatic Drug-Metabolizing Cytochrome P450 2C19 Enzyme

Abstract Despite the fact that cytochrome P450 2C19 (CYP2C19) is an essential xenobiotic-metabolizing enzyme in many drug metabolisms, the real-time and dynamic monitoring of its activity remains challenging due to the lack of highly specific activity-based probes with translatio...