Weili Heng

A Microneedle Platform Co-loaded with Eugenol, Chlorogenic Acid, and Allopurinol for In Vivo Modulation of Pathological Crystal Formation in Experimental Gouty Arthritis

Abstract Gouty arthritis arises from pathological deposition of monosodium urate (MSU) crystals, whose interactions with surrounding tissues initiate and amplify inflammation. Here, we developed a nanoengineered microneedle (MN) platform for localized modulation of pathological c...

Temperature-Dependent Crystallization Pathways ofthe Curcumin-Magnolol Coamorphous System: A Mechanistic Study IntegratingThermodynamics and Kinetics

Abstract Coamorphous drug systems have received increasing interest owing to their potential to improve the solubility, dissolution, and bioavailability of insoluble drugs. However, coamorphous systems exist in a high-energy state, making them prone to crystallization into stable...