Weikang Ling

Spermidine attenuates copper overload-induced cuproptosis in porcine granulosa cells through the miR-194a-5p/DLAT axis

Abstract Excess copper disrupts mitochondrial metabolism by triggering cuproptosis, a regulated cell-death program characterized by the aggregation of lipoylated tricarboxylic acid cycle proteins and the loss of Fe-S cluster proteins. This mitochondrial injury may be particularly...