Weijia Shen

Ruthenium‐Catalyzed Nitrile‐Acrylate Reductive Coupling by 2‐Propanol: Synthesis of Enantioenriched β‐Amino Esters

ABSTRACT Using a ruthenium catalyst derived from RuHCl(CO)(PPh 3 ) 3 and Cy‐BIPHEP, 2‐propanol‐mediated reductive coupling of phenyl acrylate with aromatic or aliphatic nitriles occurs to form α,β‐unsaturated β‐amino esters. Although the reaction products, which incorporate acycl...