Weige Dong

Strain-specific magnetic nanoantidote with lipopolysaccharide recognition for systemic immune reprogramming in drug-resistant sepsis

Sepsis mortality is exacerbated by the endotoxin paradox, wherein conventional antibiotic-induced bacterial lysis triggers massive lipopolysaccharide (LPS) release, often culminating in an irreversible cytokine storm. Addressing the structural heterogeneity of the LPS O-antigen t...

A Cross‐Kingdom Counter‐Mimicry Nanozyme Reverses Fungal‐Induced Neutrophil Paralysis and Establishes Protective Immune Memory

ABSTRACT Recurrent fungal infections caused by Candida albicans remain a formidable clinical challenge due to the pathogen's sophisticated orchestration of immune evasion. Herein, we report a “kill‐and‐reset” nano‐platform comprising a CuFe dual‐atom nanozyme core encapsulated wi...