Weidong Zang

The primary somatosensory cortex mediates trigeminal neuralgia induced depressive-like behaviors through an indirect pathway targeting the lateral habenula

Abstract Background Trigeminal neuralgia frequently co-occurs with depression, aggravating clinical outcomes. The primary somatosensory cortex (S1), a key pain-processing region, exhibits hyperactivity linked to chronic pain. Moreover, S1 integrates nociceptive inputs to modulate...