Wei Zhang

A low-complexity, tissue-function-guided engineering workflow for AlphaFold 3-assisted affinity maturation of a CD21 diagnostic nanobody

High-affinity antibodies with reliable tissue-staining performance are needed for reproducible immunohistochemistry (IHC), yet affinity maturation workflows often optimize recombinant-antigen binding and treat staining in formalin-fixed, paraffin-embedded tissue as a downstream v...

Surface-Engineered Phytochemical Nanomedicines for Postmenopausal Osteoporosis: Skeletal Targeting, Imaging-Supported Evaluation, and Therapeutic Performance

Postmenopausal osteoporosis (PMOP) is a metabolic bone disease driven by estrogen deficiency and a major contributor to fragility fractures, yet long-term use of current antiresorptive and anabolic agents remains constrained by tolerability and adherence. Plant-derived bioactive...