Wei Yi

Mechanochemical Encapsulation of Enzymes in a Highly Hydrophilic HOF: Harnessing Pore Microenvironment for Enhanced Biocatalysis

ABSTRACT Enzymes immobilized within hydrogen‐bonded organic frameworks (HOFs) often suffer from reduced catalytic activity due to mass transfer limitations and pore channel blocking by residual organic solvents from conventional solution‐phase synthesis. In addition, the correlat...

Ring Expansion of Benzothiaselenazole-1-oxides via Five-Membered Selenonium Ion-Mediated Alkene Insertion into Se–N Bonds

Abstract Ring expansion of heterocyclic frameworks provides an efficient approach to structurally diverse bioactive molecules, yet such transformations of organoselenium heterocycles remain largely unexplored. Herein, we report a calcium-catalyzed insertion of alkenes into the Se...

Umpolung at the meta ‐Positions of Oxazino‐Pyridines Enabling Nucleophilic Pyridine Functionalization

ABSTRACT Selective C─H functionalization of azines is of paramount importance to synthetic and medicinal chemistry. However, nucleophilic functionalization at meta‐ position of pyridines has remained elusive because of the intrinsic polarity mismatch. In this study, we report a m...

Umpolung at the meta ‐Positions of Oxazino‐Pyridines Enabling Nucleophilic Pyridine Functionalization

Selective C─H functionalization of azines is of paramount importance to synthetic and medicinal chemistry. However, nucleophilic functionalization at meta-position of pyridines has remained elusive because of the intrinsic polarity mismatch. In this study, we report a mild and pr...