Wei Pang

CD4+ cytotoxic T cells: context-dependent effectors in health and disease

Abstract Cytotoxic CD4 + T cells (CD4 + CTLs) have been identified as a specialized effector population characterized by potent cytotoxic machinery, including granzymes, perforin, and the Fas/FasL pathway, that enables the direct killing of MHC-II-expressing target cells. In addi...

Differential modulation of ferroptosis pathways by NOX1/4 and NLRP3 inhibition in DSS-induced colitis

Ferroptosis contributes to the pathogenesis of inflammatory bowel disease, but how NOX1/4 and NLRP3 pathways regulate this process remains unclear. This study aimed to investigate the therapeutic effects and mechanisms of the NOX1/4 inhibitor Setanaxib (SET) and the NLRP3 inhibit...