Wei Hong

Cynarin Targets Host CX3CR1 for Dual-Action Prophylaxis against RSV Infection and Pulmonary Pathology

Abstract Safe, small-molecule prophylactic agents against respiratory syncytial virus (RSV) are critically lacking. Here, we identify Cynarin, an artichoke-derived dietary polyphenol, as a micromolar affinity CX3CR1 antagonist. Mechanistically, Cynarin confers dual-action protect...