Wei-Chen Chu

Notch-hedgehog antagonism regulates stem cell niche formation through an E2-E3-E3 ubiquitin module

Abstract Distinct microenvironments, including the stem cell niche and differentiation zone, promote stem cell self-renewal and progeny differentiation, yet how these domains are established remains unclear. In the developing Drosophila ovary, we show that Notch activation silenc...

Whole-organ single-cell mapping defines growth dynamics and clonal organization in developing and adult zebrafish livers

Vertebrate organs undergo massive growth during the post-embryonic period. Yet, our understanding of how this organ-wide process is organized at single-cell resolution has been limited by an inability to monitor individual cells of different types throughout intact adult organs....