Wei Alex Wang

Orthogonal Light‐ and Enzyme‐Triggered and‐Gate Prodrugs for Senolytic Therapy

ABSTRACT Senescence‐associated β‐galactosidase (SA‐β‐gal) is widely used to target senescent cells, but its activity in non‐senescent tissues can limit selectivity. Here, we developed a light–enzyme AND‐gate strategy in which an o‐nitrobenzyl photocage blocks β‐galactoside cleava...