Wataru Ise

In vitro induction of human germinal center B cells

During antibody responses, germinal centers (GCs) act as a key site for somatic hypermutation (SHM) and affinity maturation of B cells. However, their lymphoid tissue localization has made experimental manipulation of human germinal center B (GCB) cells difficult. Here, we descri...

Positive selection of IgG over IgM plasma cells through BCR isotype–specific antigen presentation and signaling

During a primary immune response, B cells can undergo isotype switching from an immunoglobulin M (IgM) B cell receptor (BCR) to an IgG BCR. B cells that have switched to IgG give rise to more bone marrow long-lived plasma cells (PCs) compared with those expressing IgM, but how BC...