Wang Shan-Feng

A novel positive feedback regulatory loop, TGF-β1/SMAD4/miR-184, controls the follicular development in sows.

transcription by binding to its promoter and forming an RNA-induced transcriptional activation complex with AGO2, CTR9, DHX9, and RNA polymerase II. Consequently, a novel positive feedback loop (TGF-β1/SMAD4/miR-184) was identified. In vitro GC and follicle culture systems valida...