Walter Rocchia

Synergistic Effects of pH and Temperature on Dengue Virus Envelope Dimers: Insights from Microsecond Molecular Dynamics Simulations

Abstract Dengue pathogenesis depends on a conformational rearrangement of the envelope glycoprotein (pE) induced by low pH. However, how pH and temperature cooperate to destabilize the dimeric form of the pE, a fundamental step that enables the formation of the fusion-active trim...