Wakako Yuji

Worsening heart failure is not a single endpoint: a severity-gradient perspective from digoxin in rheumatic heart disease

Abstract The composite of cardiovascular or all-cause death and worsening heart failure (WHF) has become the principal efficacy endpoint of heart failure trials. Yet WHF is not one event: it spans outpatient oral-diuretic escalation, urgent intravenous-diuretic visits, hospitalis...