Vladimir Nikolaevich Uversky

Chaperonopathies as Disorders of Disorder: The Role of Intrinsically Disordered Regions in Proteostasis Dysfunction

Abstract Molecular chaperones are central regulators of the proteostasis network, ensuring proteome integrity through protein folding, the prevention of aggregation, and targeted degradation. These mechanisms are essential for limiting proteotoxic stress and preventing the accumu...