Vincenzo Silani

Clinimetrics of the Shortened Frontal Assessment Battery (FAB15) in Neurodegenerative Disorders

This study aimed to provide a clinimetric evaluation of the shortened Frontal Assessment Battery (FAB15) in a large cohort of patients with neurodegenerative disorders. FAB15 scores were retrospectively retrieved from 379 patients with neurocognitive disorders and 260 healthy con...

Tau isoform mapping across tissues and biofluids reveals a signature distinguishing Alzheimer’s disease from amyotrophic lateral sclerosis

Abstract Blood phosphorylated tau 217 (p-tau217) accurately detects Alzheimer’s disease (AD) pathology but is also elevated in amyotrophic lateral sclerosis (ALS), likely reflecting peripheral (big) tau released from muscle. Assays selectively measuring brain-derived (BD-) tau an...